Dr Eric Paquet

PhD

Ph.D, Department of Biochemistry, McGill University

Projects :

  • Absolute single sample assignments in breast cancer
  • Breast cancer subtypes comparison
  • Breast cancer models evaluation
Education :
  • BSc Computer Science, Sherbrooke University, Quebec, Canada
  • MSc Computer Science, Montreal University, Quebec, Canada
Interests :
  • Applied machine learning
  • Development of robust and absolute prognostic and predictive multigene signatures in Breast Cancer
  • Personalized and Precision medicine
  • Tumor heterogeneity inference
Awards and Scholarships:
  • McGill Max Stern Recruitment Award, 2011
  • FRSQ Doctoral scholarship 2012-2015, decline
  • CIHR Banting and Best Doctoral scholarship 2012-2015
Selected publications: (* = first authorship)

DNA Repair Pathways in Trypanosomatids: from DNA Repair to Drug Resistance. MM Genois, ER Paquet, MCN Laffitte, R Maity, A Rodrigue, M Ouellette et al. Microbiology and Molecular Biology Reviews 78 (1), 40-73 2014

Next-generation biobanking of metastases to enable multidimensional molecular profiling in personalized medicine. Z Diaz, A Aguilar-Mahecha, ER Paquet*, M Basik, M Orain, E Camlioglu et al. Modern Pathology 26 (11), 1413-1424 4 2013

Redirecting splicing with bifunctional oligonucleotides. JP Brosseau, JF Lucier, AA Lamarche, L Shkreta, D Gendron, E Lapointe, P Thibault, E Paquet et al.. Nucleic acids research, 2013

Exchange of associated factors directs a switch in HBO1 acetyltransferase histone tail specificity. ME Lalonde, N Avvakumov, KC Glass, FH Joncas, N Saksouk, M Holliday, E Paquet et al. Genes & development 27 (18), 2009-2024 3 2013

Quantitative proteomics profiling of the poly (ADP-ribose)-related response to genotoxic stress. JP Gagné, É Pic, M Isabelle, J Krietsch, C Éthier, E Paquet, I Kelly et al. Nucleic acids research 40 (16), 7788-7805 2012

Conserved molecular interactions within the HBO1 acetyltransferase complexes regulate cell proliferation. N Avvakumov, ME Lalonde, N Saksouk, E Paquet, KC Glass, AJ Landry et al. Molecular and cellular biology 32 (3), 689-703 2012

A key role for poly (ADP-ribose) polymerase 3 in ectodermal specification and neural crest development. M Rouleau, V Saxena, A Rodrigue, ER Paquet, A Gagnon, MJ Hendzel et al. PloS one 6 (1), e15834 5 2011

Role for miR-204 in human pulmonary arterial hypertension. A Courboulin, R Paulin, NJ Giguère, N Saksouk, T Perreault, J Meloche, ER Paquet et al. The Journal of experimental medicine 2008 (3), 535-548 2011

HBO1 HAT complexes target chromatin throughout gene coding regions via multiple PHD finger interactions with histone H3 tail. N Saksouk, N Avvakumov, KS Champagne, T Hung, Y Doyon, C Cayrou, E Paquet et al. Molecular cell 33 (2), 257-265 2009

Modeling an evolutionary conserved circadian cis-element. ER Paquet*, G Rey, F Naef. PLoS computational biology 4 (2), e38 2008

Multiple alternative splicing markers for ovarian cancer. R Klinck, A Bramard, L Inkel, G Dufresne-Martin, J Gervais-Bird, R Madden, ER Paquet et al. Cancer research 68 (3), 657-663 2008

Functional and structural basis for a bacteriophage homolog of human RAD52. M Ploquin, A Bransi, ER Paquet, AZ Stasiak, A Stasiak, X Yu et al. Current Biology 18 (15), 1142-1146 2008

Multiple and specific mRNA processing targets for the major human hnRNP proteins. JP Venables, CS Koh, U Froehlich, E Lapointe, S Couture, L Inkel, A Bramard, ER Paquet et al. Molecular and cellular biology 28 (19), 6033-6043 2008

Anticancer drugs affect the alternative splicing of Bcl-x and other human apoptotic genes. L Shkreta, U Froehlich, ER Paquet, J Toutant, SA Elela, B Chabot. Molecular cancer therapeutics 7 (6), 1398-1409 2008