Mike Hallett

Principal investigator
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michael.hallettobfuscate@concordia.ca
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At McGill, we developed computational and systems biology approaches to the study of breast cancer. We have been involved in studies using high-throughput profiles in both mouse models of breast cancer and the human disease. Two of our main focuses in the lab have been (i) towards the development of gene panel that are predictive of patient outcome, response to therapy, or disease progression, and (ii) towards the development of patient subtyping methdology. The lab has a tradition of analyzing microenvionmental, macroenvironmental and systemic patient repsones, with an emphasis on the development of methodology for surrogate tissue analyses. In this sense, we are interested in developing tool that provide a global perspective of the dynamics of the disease.

Now at Concordia, our interests are evolving. For breast cancer, we are developing methods for progression studies in both early and late stage cohorts using single cell profiling techniques. We are also initiating projects to study the reef microbiome and human-fungal interactions. Professor

Education, Employment:

  • 2017-                         Professor, Department of Biology, Concordia
  • 2017-                         Member, Centre for Applied Synthetic Biology, Concordia
  • 2017-                         Member, Centre for Structural and Functional Genomics, Concordia
  • 2017-                         Affiliate, Computer Science and Engineering, Concordia
  • 2017-                        Adjunct Professor, McGill University
  • 2006-2017                Associate Professor, School of Computer Science, McGill
  • 2004-2017                Associate Member, Department of Biochemistry, McGill
  • 2009-2015                Director/PI, McGill-CIHR Training Program in Systems Biology
  • 2008-2015                Goodman Cancer Centre, McGill University, Full Member
  • 2007-2008                Visiting Scientist, German Cancer Research Centre (DKFZ), Heidelberg
  • 2006-2010                Director, McGill Centre for Bioinformatics
  • 2000-2006                Interim Director, McGill Centre for Bioinformatics
  • 2000-2006                Assistant Professor, School of Computer Science
  • 1998-2000                Oberassistant ETH, Zurich, Switzerland
  • 1996-1998                Postdoc ETH, Zurich, Switzerland
  • 1996                          Ph.D. in Computer Science at the University of Victoria, Canada
  • 1992                          B.Sc. in Computer Science at Queen’s University, Kingston, Canada
  • 1991                          Research Assistant at Queen’s University (Graph theory)

Awards and Scholarships:

  • 2018                          CRC Tier 1 Algorithmic Bioinformatics
  • 2008                          Alexander von Humboldt Fellow, Germany
  • 2001                          FCAR (Fonds pour la Formation de Chercheurs), Quebec
Invited Lectures (SELECTED)
  • 2018 PERFORM Centre, Montreal, Canada. Surveillance studies in breast cancer: novel approaches using single cell sequencing.
  • 2017 BIRS-CMO CMO Workshop Challenges and Synergies in the Analysis of Large- Scale Population-Based Biomedical Data, Oaxaca, Mexico. Molecular interactions between the systemic response and the primary tumor in a cohort of breast cancer patients.
  • 2017 Concordia Department of Biochemistry Seminar, Montreal, Canada. Gene set predictors in cancer to predict clinical end-points
  • 2016 Princess Margaret Hospital Seminar Series, Toronto, Canada. Absolute approaches to predicting patient subtype.
  • 2015 4th Canadian Cancer Research Conference, Montreal, Canada. Robust, integrative and absolute subtyping in breast cancer.
  • 2015 Concordia Institute for Genomics, Montreal, Canada Understanding the interplay between subtype and prognosis in an absolute manner.
  • 2014 University of Paris Descartes, Paris, France. The inherent ease and difficulty of prognosis in breast cancer.
  • 2014 SciLifeLabs, Karolinska Institute, Stockholm Sweden. The prognostic ease and difficulty of invasive breast carcinoma.
  • 2014 University of Paris Descartes, Paris, France. The inherent ease and difficulty of prognosis in breast cancer.
  • 2013 Goodman Cancer Centre. Landscape of prognosis in Breast Cancer. Montreal,Canada
  • 2013 Canadian Breast Cancer Research Consortium. Inherent difficulty in breast cancer. Toronto, Canada
  • 2013 Montreal -Toronto Systems Biology Computational Retreat, McGill University
  • 2013 CIHR Genetics and Statistical Genetics Meeting. The inherent difficulty of breast cancer prognosis.  Esterel, Canada
  • 2013 4th IRCM Meeting on Systems Biology. The prognostic landscape of breast cancer: the illusion of Accuracy. Montreal, Canada
  • 2012 Radium Hospital. The Illusion of Accuracy in Breast Cancer Prognosis. Oslo, Norway
  • 2011 Radium Hospital. The existence of inherently difficult prognostic breast cancer patients. Oslo, Norway
  • 2011 Vancouver Oncology-Bioinformatics Meeting, A fresh perspective on prognostic prediction in breast cancer. Vancouver, Canada
  • 2010 Montreal Symposium on Bioinformatics, A systems approach to understanding breast cancer. Montreal, Canada
  • 2010 The NOWAC Symposium, Gene expression approaches in cancer research. Tromso, Norway
  • 2009  B.R.I Meeting. A Systems approach to understanding breast cancer. Moncton, Canada
  • 2009 Human Proteome Organization. Towards a systems approach to understanding breast cancer. Toronto, Canada
  • 2009 Canadian Student Conference on Biomedical Computing, UBC, A systems approach to understanding breast cancer progression Vancouver, Canada
Funding Committees, Editorial Boards:
  • 2017-. Editorial board. PeerJ.
  • 2014-2017. CIHR, Foundation Grants Competition, Virtual Chair.
  • 2012-2016. CIHR, Genomics (GMX) panel, Chair.
  • 2012-2014. Canadian Cancer Society Research Institute, Gene Regulation panel, Member.
  • 2010, 11, 13, 18. Ontario Research Foundation, Member.
  • 2011-2012. Terry Fox Cancer Research Society, Panel Member.
  • 2005-2010, 2012. CIHR, Genomics (GMX) panel, Member.
  • 2009. CIHR, Biochemistry & Molecular Biology – B panel, Member.
  • 2007. CIHR, Proof of Principle, Member.
  • 2010. CIHR Strategic Group for Epigenomics and Personalized Medicine.
  • 2003-2005. NSERC Biosciences A panel, Member.
  • 2004, 2006, 2008. CIHR Tools & High Risk, Member.
Conference Committees (SELECTED):
  • 2013. Canadian Cancer Research Conference, Cancer Informatics Symposium, Chair.
  • 2013. Canadian Cancer Research Conference, General Program Committee, Member.
  • 2006- present. RECOMB Satellite Cancer Computational Biology, Steering Committee & Founder.
  • 2008, 2009, 2014. Intelligent Systems for Molecular Biology, Review Committee, Member.
  • 2012. CIHR Priority Review Committee, Member.
  • 2008. Robert Cedegren Colloquium, University of Montreal, Programme Committe, Member.
  • 2008. Canadian Society for Biochemistry and Molecular Cell Biology, Programme Committee, Member.
  • 2007. 1st RECOMB Cancer Computational Biology Meeting, San Diego. Approximately 100 researchers met in August to discuss computational and statistical aspects of computational oncology research. Scientific and Organizing Committee, Member.
  • 2007. 3rd Workshop on Bioinformatics at Bertinoro, Italy. Approximately 45 researchers met to discuss research in computational biology.
  • 2006. Canadian Consortium of Regulomics Computational Regulomics Training Program, Coordination Committee, Member.
  • 2006. Asia-Pacific Bioinformatics Conference. Hong Kong, China, Programme Committee, Member.
  • 2005. Computational Biology in the Post-Genomic Era. Montreal, Quebec. Scientific Committee Chair.
  • 2005. Workshop on Bioinformatics (WABI), Ibiza, Spain, Programme Committee, Member.
  • 2005, 2003. 1st and 2nd Fixed Parameter Algorithms Workshop. Dagstuhl meeting covering fixed parameter algorithms.
  • 2004. International Workshop on Parameterized and Exact Computation (IWPEC), Bergen, Norway, Programme Committee, Member.
  • 2003. European Symposium on Algorithms - Experimental Track (ESA-B). Budapest, Hungary, Programme Committee, Member.
  • 2003. COCOON ’03, Montana, U.S. Programme Committee, Member.
  • 2002, 2003. 1st and 2nd Canadian Computational Biology Workshop. Two day event held in conjunction with the IBM CASCON conference, Toronto.
  • 2001. Annual International Conference on Research in Computational Biology (RECOMB). Montreal, Quebec. Organizing Committee, Member.
  • 2001. Workshop on Bioinformatics (WABI). Aarhus, Denmark. Programme Committee, Member.
  • 2001. International Conference on Discrete Mathematics and Theoretical Computer Science. Constanta, Romania. Programme Committee, Member.
My lab organizes the annual workshop at McGill-Bellairs Research Station in Barbados.

 

Papers

The complex subtype-dependent role of Connexin 43 (GIA1) in breast cancer

Building applications for interactive data exploration in systems biology

Interactions between the tumor and the blood systemic response of breast cancer patients

Identification of interacting stromal axes in triple-negative breast cancer.

Detecting gene signature activation in breast cancer in an absolute, single patient manner

Discovery of stromal regulatory networks that suppress Ras-sensitized epithelial cell proliferation

Publications in 2016

Publications in 2015

Publications in 2014

Publications in 2013

Publications in 2012

Publications in 2011

Publications in 2010

Publications in 2009

Publications in 2008

Publications in 2007

Publications from 2004-2006

Publications from 1996-2003

Publications from 1993-1995

Posts

Institue for Research in Immunology and Cancer Annual International Symposium

First International Symposium on Mathmematical and Computational Oncology

Attending RECOMB-Comparative Genomics in Orford, Quebec

Overview of the state of cancer from the Canadian Cancer Society 2018

Genome Project Write workshop

Mike will be at ASCO 2018

Mike attended Concordia BioMed Connect

Roundtables for Systems and Information Biology at Concordia

But soft, what light through yonder window breaks?

Tacos, sushi and the end of the world

The development of genomics based surveillance studies in breast cancer

Retrospective Events for 2018

Retrospective Events for 2017

Retrospective Events for 2016

Retrospective Events for 2015